How do you see this one playing out? The New Orleans Saints (0-3) and Buffalo Bills (3-0) are set to kick off in Week 4, and our staff writers predict a bloodbath. It’s not hard to see why. One team has Super Bowl aspirations. The other is hoping for their first win this year, and just their second victory since last Thanksgiving.

Let’s see if they can keep it close. Here are our picks. What are yours?

Bills 30, Saints 23

I fully expect the Buffalo Bills offense to run wild this week, but their defense is a real problem. They’re almost as bad as the New Orleans Saints have been themselves through three weeks. Buffalo is giving up third down conversions at a rate of 43.2%; New Orleans is just ahead of them at 45.9%. The Bills haven’t defended the red zone well, either, with 5 of 7 drives ending with a touchdown (71.4%). The Saints are 8-for-10 (80%). Sean McDermott’s unit is averaging 2.4 points allowed per drive. Brandon Staley’s squad is giving up 2.57. Don’t be shocked if the Saints keep pace. Bold prediction: Alvin Kamara runs for 100-plus yards and scores twice. No team is giving up more yards per carry (6.2) or per game (156) than the Bills, and they’re going to be without key defenders Ed Oliver and Matt Milano this week due to injuries. Those guys are difference-makers. — John Sigler

Bills 38, Saints 10

The New Orleans Saints are getting worse and worse by the week, with a brutal loss to the Seattle Seahawks showcasing their true form as a bottom team in the NFL. Some think there may be a turnaround for this team, but the odds that it occurs against the Buffalo Bills is basically 0%. Buffalo is one of those teams that kills the regular season and takes care of business against lesser squads, this should be one of those games, and the Saints won’t have much say in it. Bold prediction: What is constituted as bold with this team? After last week who knows. My bold prediction is the Saints run game actually manages to eclipse 100 yards despite the loss. — Jeremy Trottier

Bills 31, Saints 13

It’s not hyperbole to suggest that Kellen Moore and the Saints are at a crossroads so early in the season. After being so unprepared and unmotivated against Seattle, I’m interested to see if Moore and the team’s young core will rebound to give the Bills a fight. If they don’t, this season could quickly spiral into the abyss that national pundits were predicting. The Saints aren’t nearly as talented as Buffalo, but it would be nice to see a close battle into the fourth quarter. I don’t think it happens. Bold prediction: Spencer Rattler gets benched midway through the third quarter for Tyler Shough, giving the rookie his first significant game action and setting the stage for a quarterback change for Week 5. — Bob Rose

Bills 40, Saints 10

The Saints have seemingly anything and everything to work on heading into the week’s matchup against the Bills — there’s a reason why the spread is this large in Buffalo’s favor. The Bills have one of the best offenses in the league, going up against a team that gave up multiple explosive plays and self sabotaged on all cylinders against the Seahawks. They shouldn’t have a hard time remaining undefeated against a reeling New Orleans. Bills 40, Saints 10. Bold prediction: The Saints lose by at least three scores. The Saints shot themselves in the foot perhaps even more than they were outmatched in the last game. They go up against an even more put together team here, coming off of a historically bad loss. — Crissy Froyd

Bills 27, Saints 21

Believe it or not, this game has the makings of a close matchup, even if the records say otherwise. The Bills are coming off a mini-bye after edging out the Dolphins, and they should be well rested for Sunday’s game against the Saints. That rest could also open the door for Buffalo to take their opponent a little lightly. That’s where the Saints might find an edge. After a rough loss to the Seahawks, they’ll be hungry to bounce back and catch someone off guard. Buffalo’s defense isn’t the same as years past, especially in the secondary, and that’s an area New Orleans could look to exploit. With a healthy offensive line and receiving corps, the Saints should be able to move the ball if they limit the mistakes that have hurt them before. Still, in the end, Josh Allen feels like the difference-maker. Expect him to come up with the big play in the fourth quarter to seal a home win for the Bills. Bold prediction: Chris Olave scores TWO touchdowns in this game, after failing to reach the end zone in the first three games

This article originally appeared on Saints Wire: Week 4 staff picks: Final score, bold predictions for Saints vs. Bills