Scotland centre Sione Tuipulotu will make his first Glasgow appearance of the new URC season when the Warriors face Benetton in Treviso on Saturday.
The British and Irish Lions star is joined in the starting XV by club captain Kyle Steyn, who returns on the wing.
The Scotland regulars are two of seven changes in the Warriors line-up. Rory Sutherland comes in at loosehead, while Gregor Brown and Maccenzie Duncan go into the back-row at blindside and openside respectively.
It’s all change in the half-backs, with Jamie Dobie and Adam Hastings starting together.
Euan Ferrie, George Horne and Dan Lancaster drop to the bench, while Scotland skipper Rory Darge misses out with an injury picked up in the opening-day win over Sharks.
He adds to an already-long injury list at Scotstoun. Summer signings Alex Craig (hamstring), Charlie Savala and Tavi Tuipulotu are already in the treatment room, while stars like Jack Dempsey, Zander Fagerson and Huw Jones continue to recover from injuries.
Jamie Bhatti, Kerr Yule and Ollie Smith miss out altogether from the squad last week.
Glasgow Warriors: McKay, Steyn (c), McDowall, S Tuipulotu, Rowe; Hastings, Dobie; Sutherland, Matthews, Richardson, Oguntibeju, Samuel, Brown, Duncan, M Fagerson.
Replacements: Hiddleston, Schickerling, Talakai, Williamson, Cummings, Ferrie, Horne, Lancaster.