The 2025-26 NFL regular season is rolling along, and Week 5 saw plenty of chaos, with multiple favorites of a touchdown or more losing outright. The Arizona Cardinals (-7.5) lost outright 22-21 to the Tennessee Titans in one of the worst losses you’ll ever see for those who had the Cardinals in a survivor contest, while the Buffalo Bills (-8) fell 23-20 at home to the New England Patriots on Sunday Night Football.
It’s never too early to look ahead to next week, though, and sportsbooks have already posted lines for every matchup.
Here are the odds for every Week 6 NFL game at BetMGM:
Thursday
Philadelphia Eagles (-7, 41.5) at New York Giants
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Sunday
9:30 a.m. ET
Denver Broncos (-7.5, 43.5) at New York Jets in London
1 p.m. ET
Cleveland Browns at Pittsburgh Steelers (-5, 37.5)
Arizona Cardinals at Indianapolis Colts (-5.5, 47.5)
Los Angeles Chargers (-5.5, 44.5) at Miami Dolphins
New England Patriots (-3.5, 46) at New Orleans Saints
Dallas Cowboys (-3.5, 49) at Carolina Panthers
Seattle Seahawks at Jacksonville Jaguars (-1, 45.5)
Los Angeles Rams (-7.5, 45.5) at Baltimore Ravens
4 p.m. ET
Tennessee Titans at Las Vegas Raiders (-6, 41.5)
Cincinnati Bengals at Green Bay Packers (-14.5, 44.5)
San Francisco 49ers at Tampa Bay Buccaneers (-2.5, 47.5)
Sunday Night Football
Detroit Lions at Kansas City Chiefs (-1.5, 49.5)
Monday
Buffalo Bills (-4, 49.5) at Atlanta Falcons
Chicago Bears at Washington Commanders (-4, 50.5)
Bye-week teams: Vikings, Texans
