Colorado football finally pulled off the ranked upset, taking down the No. 21 Iowa State Cyclones 24-21 Saturday evening at Folsom Field.
After missing the opportunity to knock off BYU and TCU, Deion Sanders’ squad did not miss the moment against the Cyclones, putting together its most complete performance of the season. The Buffs got the best version of Kaidon Salter, with the senior quarterback throwing for 255 yards and two touchdowns while adding 57 rushing yards on the ground.
CU’s defense gave up a ton of yards (441 yards), but held Iowa State to just 2 for 12 on third downs and got a crucial interception from safety Tawfiq Byard that prevented a Cyclone scoring drive.
Buff Nation was rightfully ecstatic with the program’s first conference win and the ranked upset. Here are the best reactions from Colorado’s best win so far this season.
RGIII knows what is up
Colorado is a MUCH better team than their record. They finally put it together and showed that off against #22 Iowa State.
— Robert Griffin III (@RGIII) October 11, 2025
This call definitely changed the whole game, but we will take it
Just so bad lol
Finally got a break their way. Iowa State fans absolutely have a real gripe. Play changed the game. Blatant PI. https://t.co/RnPjxReLKi
— Mat Smith (@RealMatSmith) October 12, 2025
Here comes the field storm!
DOWN GOES #22 IOWA STATE!!!
COLORADO WINS!! pic.twitter.com/vHnkmcwyDb
— Jake Schwanitz (@JakeDNVR) October 11, 2025
Michael Irvin loves what he saw from Dallan Hayden
Michael Irvin was hyped on running back Dallan Hayden after the #CUBuffs upset win over No. 22 Iowa State pic.twitter.com/GEAB8RBNqy
— Ben Armendariz (@BenArmendariz_) October 11, 2025
It was a great win indeed
What an insanely good win for The Buffs!!
Conversely, this is an atrocity for Matt Campbell and Iowa State
— Coach Mike Sanford (@Coach_Sanford2) October 11, 2025
Kaidon Salter showed out and sealed the win
Salter hitting that throw to win the game was special. It’s been pretty rough, but he deserves credit for a really huge play.
— Tyler Ziskin (@TZiskBuffs) October 11, 2025
Coach Prime was an inspiration
Surgery for blood Clots and back and practice the next day. Then comes out and beats the #22 team in the country. Shout out Prime man. Season not over
— Presidential (@PresidentialG_) October 11, 2025
Bye week just got a whole lot better
got it into the house 🥵
enjoy your week off ✌️ pic.twitter.com/RicsxwTlyj
— Mat Smith (@RealMatSmith) October 11, 2025
Huge performance from the offensive line
We gave up 0 sacks to wow
— Dalvinthetruth (@dalvinthetruth) October 12, 2025
A win to be proud of, that is for sure
Proud of Deion Sanders and the Colorado Buffaloes. They dropped back-to-back games. Prime had health issues to address. But today, they showed their resilience after taking down No. 22 Iowa State! 👏🏾
— GOWIE (@DaKidGowie) October 12, 2025
Is Colorado back into bowl contention?
Colorado’s record isn’t indicative of the quality of this team
Losses to Georgia tech, Houston, BYU + TCU
Those are 4 top 25ish teams (Houston fringe top 25h)
Colorado was in all of these games and just beat a good Iowa State team. Tough schedule but definitely a bowl team
— ayjay (@ayjayg_15) October 12, 2025
Colorado’s locker room was hyped
Post-game locker room vibes after upsetting No. 22 Iowa State!
You can’t tell me our Buffs didn’t just get a monkey off their backs! 🦬
(🎥: @deionsandersjr on IG)#CUBuffs#SkoBuffs#CollegeFootballpic.twitter.com/ISs9Eig5to
— Ossacin’s Ducktail (@OssacinDucktail) October 11, 2025
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This article originally appeared on Buffaloes Wire: Social media reactions to Colorado football’s win over Iowa State
