Nature Biotechnology, Published online: 05 December 2025; doi:10.1038/s41587-025-02954-9

This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecific molecules that trick HIV out of cells to destroy them; how Brazil is producing its own affordable CAR T cells; and the shift in regulators’ demands for animal testing for certain drug classes.