NFL Week 10 bold predictions & key matchups: Maye vs. Mayfield, hoss fight NFC showdown, can 49ers survive the Rams?

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NFL Week 10 bold predictions & key matchups: Maye vs. Mayfield, hoss fight NFC showdown, can 49ers survive the Rams?

November 6, 2025

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Nate Tice & Charles McDonald dive into the Week 10 NFL slate with bold predictions, matchups to watch and more. The two hosts start off by getting Lost in the Sauce with their three favorite games of the week, including Drake Maye vs. Baker Mayfield in the Tom Brady Bowl, the Pittsburgh Steelers facing the Los Angeles Chargers on Sunday night and a Hoss Fight in Wisconsin as the Philadelphia Eagles take on the Green Bay Packers.

Later, Nate & Charles give one key matchup to watch in the San Francisco 49ers vs. Los Angeles Rams battle before revealing their Hail Mary bold predictions for the weekend.

(2:30) – New England Patriots @ Tampa Bay Buccaneers preview

(24:00) – Steelers @ Chargers preview

(39:25) – Eagles @ Packers preview

(56:00) – Cheat Sheet: Rams @ 49ers

(1:00:50) – Hail Mary bold predictions

FOXBOROUGH, MASSACHUSETTS - NOVEMBER 2: Drake Maye #10 of the New England Patriots reacts prior to an NFL football game against the Atlanta Falcons at Gillette Stadium on November 02, 2025 in Foxborough, Massachusetts. (Photo by Michael Owens/Getty Images) — FOXBOROUGH, MASSACHUSETTS – NOVEMBER 2: Drake Maye #10 of the New England Patriots reacts prior to an NFL football game against the Atlanta Falcons at Gillette Stadium on November 02, 2025 in Foxborough, Massachusetts. (Photo by Michael Owens/Getty Images)

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