Until now, it has been technically nearly impossible to rotate highly sensitive samples in all directions under a microscope without making contact. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a new laser-based technique that allows microscopic samples such as cells to be rotated contact-free in all three spatial directions. The laser creates tiny temperature differences in the liquid, which trigger gentle fluid flows that move the sample. This protects delicate samples and enables more accurate three-dimensional images—an important step for basic medical research.